Last updated: Chromosomal instability as a mechanism of radiation sensitivity Chromosomal Instability (CIN) is an ongoing rate of chromosome missegregation events over the course of multiple cell divisions, and is common in human tumors. Our laboratory and others have shown that combining two independent insults that each cause tolerable levels of CIN results in high …
Last updated: Predictive biomarkers Treatment decisions for cancer have historically been based on tissue of origin and other pathologic and clinical variables which give prognostic information on the overall level of aggressiveness of a tumor. Predictive biomarkers on the other hand are used to predict response to specific treatments, rather than overall prognosis. For example, …
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Last updated: In Situ Tumor Vaccination In situ tumor vaccination is a therapeutic strategy that seeks to convert a patient’s own tumor into a nidus for enhanced presentation of tumor-specific antigens in a way that will stimulate and diversify an anti-tumor T cell response. Radiation therapy elicits an anti-tumor effect through induction of DNA damage in …
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Last updated: Targeted radionuclide therapy (TRT) and chimeric antigen receptor (CAR) T cell therapy are emerging therapies that have revolutionized cancer therapy. However, each of these therapies is confronted by limitations that can potentially be resolved by the other. As such, understanding the mechanisms that govern the interactions between these novel therapies and ways to …
Last updated: Genome surveillance and cell growth regulation There are currently two active projects that broadly pertain to mechanisms of genome surveillance growth regulation and tumor suppression. Molecular pathogenesis of ALS ALS is a fatal neurodegenerative disease that affects motor neurons. Recent genetic advances have identified genes that are critically involved in the ALS disease …