Clinical Research
We continually strive to improve cancer care through clinical trials and research based on our collective experience treating patients.
Our clinical faculty engage in research on a wide variety of cancer types to provide the highest quality cancer treatment. It’s a collaborative effort. We work with cancer biologists and medical physicists to investigate ways to improve cancer care. Patients play an essential role as well by participating in clinical trials and allowing us to collect and study their tissue samples. Our retrospective research—review of the treatments and outcomes of our patients—offers insights that could provide the basis for clinical trials that drive advances in cancer care.
Radiotherapy List – Updated July 2026
| CNS protocols | Open to Accrual | A Randomized Phase III Study Comparing Temporally-Modulated Pulsed Radiation Therapy (TMPRT) Versus Standard Radiation Therapy With Temozolomide for Adults With Newly Diagnosed MGMT-Unmethylated Glioblastoma (NRG-CC017) |
| Breast | Open to Accrual | A Phase II Study of Real-Time MRI-Guided 3-Fraction Accelerated Partial Breast Irradiation in Early Breast Cancer (MAPBI) (UW18099) |
| GI | Open to Accrual | A Phase I Study of OAR-Based, Dose Escalated SBRT with Real Time Adaptive MRI Guidance for Liver Metastases (UW18110) |
| GU | Open to Accrual | Phase III Study of Local or Systemic Therapy INtensification DIrected in Prostate CAncer Patients with Post-ProstaTEctomy Biochemical Recurrence (INDICATE) (EA8191) |
| GU | Open to Accrual | A Phase II Study of Lutetium Lu 177 Dotatate in Metastatic Prostate Cancer with Neuroendocrine Differentiation (NCI10487) |
| GU | Open to Accrual | The Phase III ‘High Five Trial’ Five Fraction Radiation For High-Risk Prostate Cancer (NRGGU013) |
| H&N | Open to Accrual | Study to identify biomarkers of oral cavity cancer response to neoadjuvant immunotherapy prior to definitive surgery (UW25009) |
| H&N | Open to Accrual | A Phase II Randomized Trial of Neoadjuvant Chemotherapy or Chemo-Immunotherapy in Patients With Recurrent/Persistent PD-L1 Enriched Squamous Cell Carcinoma of the Head and Neck Undergoing Salvage Surgery (Neopolis) (NRGHN015) |
| Lung | Open to Accrual | Phase III Prospective Randomized Trial of Primary Lung Tumor Stereotactic Body Radiation Therapy Followed by Concurrent Mediastinal Chemoradiation for Locally Advanced Non-Small Cell Lung Cancer (NRGLU008) |
| Lung | Open to Accrual | The Cardiac Radiation Therapy Sparing (HEARTS) for Thoracic Cancers (UW25019) |
| Multi-site | Open to Accrual | Phase 1 Study of Y-NM600 in Patients Receiving Anti-PD-1 or Anti-PD-L1 Therapy for Metastatic Cancer (UW24136) |
| Multi-site | Open to Accrual | Clinical Evaluation of a Treatment Planning Software and Oncology Information System for Proton Therapy (UW26028) |
| Non-Interventional | Open to Accrual | Proton and Photon Consortium Registry (PPCR): A Multi Center Registry of Pediatric Patients treated with Radiation Therapy (UW24091) |