University of Wisconsin School of Medicine and Public Health
The following are descriptions of several motion management research projects that our medical physicists are currently pursuing: Evaluating the performance of the optical surface imaging systems Dustin Jacqmin, PhD Optical surface imaging systems like AlignRT and the Varian Optical Surface Monitoring System (OSMS) are often used for monitoring patients during frameless stereotactic radiosurgery (SRS). This …
The following are descriptions of several imaging research projects that our medical physicists are currently pursuing: Dual Energy Computed Tomography for Bone Delineation Michael Lawless, PhD Using the tools available to us as a part of the Siemens Somatom Definition Edge Dual Energy CT (DECT) scanner, we have the ability to better visualize tissues that …
The following are descriptions of several clinical operations research projects that our medical physicists are currently pursuing: Clinical Impact of Treatment Delivery Errors in Radiotherapy The goals of this work are to produce clear guidelines on uncertainty impacts, to support clinical decisions on robust treatment methods, to aid in the optimization of verification approaches and …
The following are descriptions of several brachytherapy research projects our medical physicists are currently pursuing: Deep Learning Tools for Automated Segmentation and Treatment Planning In Brachytherapy We have developed in-house deep learning based segmentation tools for HDR prostate brachytherapy that outperform commercial alternatives in accuracy. Ongoing research is focused on improving model performance and extending …
The following are descriptions of several adaptive radiotherapy research projects that our medical physicists are currently pursuing: MRI-guided Adaptive Radiation Therapy MRI-guided radiation therapy provides a method by which we are able to observe daily changes in the patient’s internal anatomy. This can be caused by many factors, ranging from reduction in tumor size to …
Last updated: Treatment Planning Strategies for Stereotactic Radiosurgery For intracranial radiosurgery treatments, we seek conformal high-dose radiation dose distributions with exceptionally sharp fall-off of the dose outside the treatment volume. Depending on the exact size, shape and location of the target volume, we have access to different treatment planning approaches to achieve these goals. We …
Last updated: Chromosomal instability as a mechanism of radiation sensitivity Chromosomal Instability (CIN) is an ongoing rate of chromosome missegregation events over the course of multiple cell divisions, and is common in human tumors. Our laboratory and others have shown that combining two independent insults that each cause tolerable levels of CIN results in high …
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Last updated: In Situ Tumor Vaccination In situ tumor vaccination is a therapeutic strategy that seeks to convert a patient’s own tumor into a nidus for enhanced presentation of tumor-specific antigens in a way that will stimulate and diversify an anti-tumor T cell response. Radiation therapy elicits an anti-tumor effect through induction of DNA damage in …
Last updated: Targeted radionuclide therapy (TRT) and chimeric antigen receptor (CAR) T cell therapy are emerging therapies that have revolutionized cancer therapy. However, each of these therapies is confronted by limitations that can potentially be resolved by the other. As such, understanding the mechanisms that govern the interactions between these novel therapies and ways to …