The Glide-Hurst Lab
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Last updated: Targeted radionuclide therapy (TRT) and chimeric antigen receptor (CAR) T cell therapy are emerging therapies that have revolutionized cancer therapy. However, each of these therapies is confronted by limitations that can potentially be resolved by the other. As such, understanding the mechanisms that govern the interactions between these novel therapies and ways to …
Last updated: Genome surveillance and cell growth regulation There are currently two active projects that broadly pertain to mechanisms of genome surveillance growth regulation and tumor suppression. Molecular pathogenesis of ALS ALS is a fatal neurodegenerative disease that affects motor neurons. Recent genetic advances have identified genes that are critically involved in the ALS disease …
Last updated: Novel Use of 0.35T ViewRay MRI-guidance for High Dose Rate Brachytherapy in the Treatment of Cervical Cancer Image-guided adaptive brachytherapy for cervical cancer has resulted in improved outcomes and/or decreased toxicity rates for many cervical patients compared to prior 2D/fluoroscopic-based planning. We sought to evaluate the 0.35T MRI on our ViewRay system for …
Last updated: My lifelong goal is to continue the path of elevated level of research in the field of radiation therapy. Millions of patients around the world are diagnosed with cancer every year. More than 50 percent of them require radiation therapy to manage their disease. During the last five decades, radiation therapy has advanced …
Last updated: For nearly two decades, balloon-based high dose-rate applicators for irradiation of breast lumpectomy cavities has been an effective treatment for women with early-stage breast cancer. Recently, our institution developed a novel double-balloon applicator that allows for a customizable distance of the radiation source from the breast tissue. However, this customizability may potentially result …
Last updated: Clinical Treatment Planning System Our problem definition is inspired by asking what we can do better for our current patients and what we would want to do if we just had the right tools on hand. Thus, significant effort is being spent on implementing a new clinical treatment planning system for patient care. …
Last updated: Magnetic Resonance Imaging (MRI)-Guided Breast Radiation The University of Wisconsin is one of the first radiation oncology clinics in the world to offer treatment with the ViewRay treatment system. This allows us to monitor patients with MRI in real time before and during the delivery of radiation therapy, ensuring the most precise treatment …
Last updated: Improving tumor delineation in the pancreas and liver through dual-energy CT Tumor delineation in the pancreas and liver can be a challenge using conventional CT images. Dual-Energy CT provides many opportunities to better delineate tumor from healthy tissue and therefore has great potential to aid in radiation therapy. The Department of Human Oncology …
Priming versus propagating: distinct immune effects of alpha- versus beta-particle emitting radiopharmaceuticals when combined with immune checkpoint inhibition in mice.Kerr CP, Jin WJ, Liu P, Grudzinski JJ, Ferreira CA, Comas Rojas H, Oñate AJ, Kwon O, Hyun M, Bio Idrissou M, Welch Schwartz R, Vera JM, Clark PA, Adeniyi A, Takashima M, Erbe AK, Shea AG, …