Brachytherapy
The following are descriptions of several brachytherapy research projects our medical physicists are currently pursuing:
Deep Learning Tools for Automated Segmentation and Treatment Planning In Brachytherapy
We have developed in-house deep learning based segmentation tools for HDR prostate brachytherapy that outperform commercial alternatives in accuracy. Ongoing research is focused on improving model performance and extending the models to gynecological applications. These tools are designed to improve workflow efficiency while reducing interuser variability
Framework for Robust Simultaneous Optimization of Catheter Positions and Dwell Times for Interstitial Brachytherapy
We designed, implemented, and validated a novel optimization framework for simultaneous optimization of catheter positions and dwell times in interstitial brachytherapy. The method improves plan quality and robustness by jointly optimizing geometry and source loading, enabling more consistent and clinically optimal dose distributions.
Implicit Neural Representation for Ultrafast Dose Calculations and Differentiable Optimization Methods for Directional Brachytherapy
We developed an implicit neural representation framework for ultrafast dose calculation and differentiable optimization in directional brachytherapy. This approach enables efficient gradient-based optimization of anisotropic source emission patterns to support focal dose escalation and biologically guided treatment planning.
Real-time Multimodality Image-Guided Brachytherapy Platforms integrating CT, MRI, PET, and Ultrasound
We developed and commissioned a real-time multimodality image-guided brachytherapy workflow that enables transfer of target structures from MRI and PET into ultrasound for intraoperative guidance. This system integrates CT, MRI, PET, and ultrasound to improve target localization and procedural accuracy during brachytherapy.
3D Printing Applications
Our team has developed expertise designing and fabricating patient-specific 3D printed brachytherapy applicators for anatomically tailored treatments. Prior innovations include developing custom pediatric applicators for which commercial alternatives did not exist. We are currently expanding our clinical capabilities to fabricate custom surface applicators for highly conformal skin brachytherapy.
Simulated Error Training
Our team has developed a simulated error training program for brachytherapy plan review in which errors were intentionally embedded within treatment plans to help train physicists to identify clinically relevant issues before treatment delivery. The project has helped improve our clinical QA checklists and workflows and has also proven to be a valuable tool for training residents and new physicists. This project is also being expanded through collaboration with the AAPM Work Group on Medical Errors in Brachytherapy to create a broadly accessible multi-vendor simulated error training resource.
Clinical Implementation of Novel Brachytherapy Techniques
Our team offers novel brachytherapy techniques including GammaTile and Eye Physics plaque brachytherapy, to expand treatment options and improve precision for intracranial and ocular malignancies.